PROJECTS 2020/1

MICRORHEOLOGY OF HUMAN MUCUS
MICROFLUIDIC DEVICE MIMICKING MUCOCILIARY CLEARENCE
ACTUATION OF MAGNETIC PILLARS
MOTION OF A FLUID PROPELLED BY THE BEATING OF MAGNETIC PILLARS

ANR Project MucOnChip

The project ANR entitled MucOnChip is a collaboration between three laboratories: Matière et Systèmes Complexes at the Université de Paris, Institut Galien from Université Paris-Saclay and Physicochimie des Electrolytes et Nanosystèmes interfaciaux (Phenix) from Sorbonne Université. It has been submitted to tha Agence Nationale de la Recherche on December 01, 2020.

The present project aims at fabrication and evaluation a of a microfluidic device which mimics the fundamental clearance functions in the bronchial region of human lungs. The micropfluidic device will be used for screening prodrugs of corticosteroids in relation with treatment of inflammatory lung diseases, such as asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

MICRORHEOLOGY OF HUMAN MUCUS

Magnetic wire undergoing rotation in human mucus as a result of an external rotating magnetic field

  • The microrheology protocol used here is based on the Magnetic Rotational Spectroscopy (MRS) technique
  • Wire length 40 µm, diameter 2.5 µm
  • Materials: iron oxide nanoparticles assembled with cationic polyelectrolytes
  • Magnetic field: 10.3 mT
  • The rotating filed is created by two pairs of coils working with a 90°-phase shift
  • The angular frequency ranges from 0.001 to 100 rad s-1

    Click on the images below to see the corresponding movies.
Angular frequency 0.0094 rad s-1
Angular frequency 0.94 rad s-1


MICROFLUIDIC DEVICE MIMICKING MUCOCILIARY CLEARENCE

Simulation of pillar bending in presence of a moving magnet

  • Click on the images below to see the corresponding movies.

ACTUATION OF MAGNETIC PILLARS

Sequence of optical microscopy images showing a pillar substrate under the application of a magnetic field

  • Pillar height 70 µm, diameter 18 µm
  • Materials: PDMS with 10 vol. % of iron particles
  • Magnetic field gradient: 5 000 – 50 000 T/m
  • Asymmetric sawtooth wave applied by a micro-manipulator holding the magnet
  • Pillars deflection 30 µm
Click on the image to open the movie

 

Click on the image to open the movie

MOTION OF A FLUID PROPELLED BY THE BEATING OF MAGNETIC PILLARS

  • Pillar height 150 µm, diameter 20 µm
  • Materials: PDMS with 10 vol. % of iron particles
  • Magnetic field gradient: 5 000 – 50 000 T/m
  • Asymmetric sawtooth wave applied by a micro-manipulator holding the magnet
  • Particles dispersed in the fluid: 1 µm PISA polymer particles
  • Observation made 50 µm above the pillar tips
  • Pillar beating frequency: 0.2 Hz
Click on the image to open the movie

 

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