Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors, biomarkers and biomachines. Current nanomedicine issues involve understanding and controlling the interactions (and toxicity) of nanoscale materials with biological body fluids, cells and tissues.
Our research focuses on tailoring nanoparticle interfaces and functionalization. In collaboration with the company SPECIFIC POLYMERS, we synthesize functional polymers that can be applied to a wide range of metallic surfaces and be supplied in large amounts. The copolymers contains multiple phosphonic acids as metal binding agents and poly(ethylene glycol) as protein resistant chains. This coating is efficient towards various metal oxide particles and substrates, including cerium, iron, titanium and aluminum oxide substrates. We have shown that such polymer coatings significantly decrease the nanoparticle uptake towards living cells and extend the lifespan of contrast agents in the blood.
Based on this platform, we have recently designed a strategy that has been extended to the treatment of ischemic stroke through the use of antioxidant cerium oxide nanoparticles.
V. Baldim, Y. Nisha, N. Bia, A. Graillot, C. Loubat, S. Singh, A.S. Karakoti and J.-F. Berret*
Polymer coated cerium oxide nanoparticles as oxidoreductase-like catalysts
ACS Appl. Mater. Interfaces 12(37), 42056–42066 (2020)
M. Falahati*, F. Attar, M. Sharifi, T. Haertlé, J.-F. Berret, R. H. Khan, and A. A. Saboury
A health concern regarding the protein corona, aggregation and disaggregation
Biochimica and Biophysica Acta – General Subjects 1863, 971 – 991 (2019)
V. Baldim, A. Graillot, N. Bia, C. Loubat and J.-F. Berret*
Mono- versus multi-phosphonic acid based PEGylated polymers for functionalization and stabilization
of metal (Ce, Fe, Ti, Al) oxide nanoparticles in biological media
Advanced Materials Interfaces 1801814 (2019)
F. Mousseau* and J.-F. Berret*
The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants
Soft Matter 14, 5764 – 5774 (2018)
V. Baldim*, F. Bedioui, N. Mignet, I. Margaill and J.-F. Berret*
The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce3+ surface area concentration
Nanoscale 10, 6971 – 6980 (2018)
N. Giamblanco*, G. Marletta*, A. Graillot, N. Bia, C. Loubat and J.-F. Berret*
Serum protein resistant behavior of multisite-bound poly(ethylene glycol) chains onto iron oxide surfaces
ACS Omega 2, 1309 – 1320 (2017)