INHALED NANOPARTICLES AND LUNG FLUIDS

Following their interaction with living organisms, nanomaterials generally do not come into contact with live cells or tissues, but first encounter extracellular body fluids around them. Upon contact, nanomaterials are then dispersed in a water-borne phase rich in electrolytes, in lipids, proteins and carbohydrates with which they interact. In the context of nanoparticles interacting with extracellular body fluids, the respiratory zone in the lungs represents an interesting environment. In this region, the alveoli form a froth-like structure and their interface with the air is lined with a thin layer (< 1 µm) of pulmonary surfactant, an interstitial fluid containing lipids and proteins. Its role is to reduce the surface tension with the air and to prevent alveolar collapse and expansion

Pertaining to their interaction mechanisms with lipids, the picture emerging from current literature is based on the protein corona model, leading to a description in terms of biomolecular or lipid coronas. In this work, we study the effects of inorganic nanoparticles on the biomolecular or lipid corona and on the impact on the bulk properties in physiological conditions.

REFERENCES

F. Mousseau*, A. Vacher, M. Airiau, S. Mornet and J.-F. Berret
Revealing the pulmonary surfactant corona on silica nanoparticles by cryo-transmission electron microscopy
Nanoscale Advances 2, 642 – 647 (2020)
https://doi.org/10.1039/C9NA00779B

L.P.A. Thai, F. Mousseau, E.K. Oikonomou, M. Radiom and J.-F. Berret*
Effect of Nanoparticles on the Bulk Shear Viscosity of a Biomimetic Lung Surfactant
ACS Nano 14, 466 – 475 (2020)
https://doi.org/10.1021/acsnano.9b06293

F. Mousseau*, J.-F. Berret*, E.K Oikonomou*
Design and applications of a fluorescent labeling technique for lipid and surfactant preformed vesicles
ACS Omega 4, 10485 – 10493 (2019)
https://doi.org/10.1021/acsomega.9b01094

L.P.A. Thai, F. Mousseau, E.K. Oikonomou and J.-F. Berret*
On the rheology of pulmonary surfactant: effect of the concentration and consequences for surfactant replacement therapy
Colloids and Surfaces B: Biointerfaces, 178, 337 – 345 (2019)
https://doi.org/10.1016/j.colsurfb.2019.03.020

F. Mousseau* and J.-F. Berret*
The role of surface charge in the interaction of nanoparticles with model pulmonary surfactants
Soft Matter 14, 5764 – 5774 (2018)
https://doi.org/10.1039/c8sm00925b

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